Name: Arne Van MolArne Van Mol Scientist Spotlight

Alcami Site: Weert, Netherlands

What is your role? 
I am a process engineer at the Alcami site in Weert, Netherlands. My role is to scale up manufacturing activities in accordance with environmental, health and safety (EH&S) and current good manufacturing practice (CGMP) requirements.

How long have you been with Alcami?
My first experience with Alcami was during my internship in 2017. I had the pleasure of supporting the scale up of an active pharmaceutical ingredient (API) starting from a 2L reactor (150 grams of API) to a 400L reactor (36 kilograms of API).

I rejoined the Alcami team in November 2018 as a full-time employee.

What is the most rewarding part of your job? 
Working closely with R&D chemists in order to solve scale up obstacles and technical issues, such as emulsified phase separations or poor conversions, is the most satisfying part of the job.

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What are your team’s latest achievements?
Recently, a three-phase system was observed in a process. The separation was to be performed where the top liquid layer needed to be isolated from a bottom bi-phasic thick slurry. The typical method for executing a phase separation left too much of the bottom layer residue in the reactor. A process was developed by our team to selectively and efficiently extract the top product layer from the reactor in an inert, closed, and safe environment, enabling the product to be run at full scale.

How do you see those accomplishments affecting the pharmaceutical and biotech industries?
The Alcami Weert team is creating scalable processes for new APIs. Together with our chemists, we are overcoming challenges to obtain the best possible yield and purity to produce enough material to support critical clinical studies. This has and continues to support the industry in bringing new drugs to the market.


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