NEWS & EVENTS

Leveraging Inductively Coupled Plasma Mass Spectrometry To Its Full Potential

Today’s technology has not only changed the way we receive information, but has continually adapted and progressed how we acquire information. The analysis of metals in pharmaceutical actives (API), raw material, and drug products has changed as well. ICP-MS/OES has emerged as a critical analytical platform for this analysis. 
Download White Paper: Leveraging ICP- MS To Its Full Potential

Alcami offers multiple ICP-MS capabilities to support this need including catalyst control, assay determination, organometallic compounds, and cleaning verification methods in addition to elemental impurities testing (raw material and product testing). All of these testing applications serve to maintain regulatory compliance and help deliver safe products to consumers.

Inductively Coupled Plasma Mass Spectrometry (ICP-MS) is a quickly growing technique in the pharmaceutical industry for its ability to deliver accurate and precise measurements of many metals within minutes. The general flow of analysis for ICP-MS starts with sample preparation, which can be as simple as diluting the sample material into a dilute acidic matrix or involve more complex preparation schemes that utilize extraction or digestion techniques. After the sample is in solution, it is aspirated into a fine, aerosolized mist that is introduced into the argon plasma. The argon plasma ionizes the atoms which then are streamlined towards the detector with the help of ion-focusing cones and lenses. Multiple configurations, including collision and reaction cell gases, can be interchanged to optimize the instrument’s ability to detect the analyte in both simple and complex sample matrices. The versatility, short analysis time, and ability to measure many elements at once make ICP-MS a better alternative to the older stand-by methods of flame and graphite furnace atomic absorption. In this white paper, we will highlight several applications of ICP-MS in the pharmaceutical industry that capitalize on the technique’s versatility outside of the scope of elemental impurities.

To read the rest of the white paper, please download here.

ICP-MS-White-Paper

Download White Paper: Leveraging ICP- MS To Its Full Potential

Topics: News & Events Analytical Testing Analytical Development White Paper / eBook Blogs icp-ms